Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494.Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328.Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834.Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human GANP.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.
Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494. Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328. Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834. Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total GANP protein.
Subcellular Location
Isoform GANP: Cytoplasm, Nucleus envelope, Nucleus, nuclear pore complex, Note=In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene, SUBCELLULAR LOCATION: Isoform MCM3AP: Cytoplasm, Nucleus, nucleoplasm