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Home / Primary Antibodies / IHC Antibodies

MAP2K1 Antibody

BHA10554867
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Tel
+1 866.986.9598
Email
[email protected]
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Uniprot Q02750
Database Links

HGNC:6840

OMIM:176872

KEGG:hsa:5604

STRING:9606.ENSP00000302486

UniGene:Hs.145442
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Pathway cAMP signaling pathway Chemokine signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway MAPK signaling pathway Melanogenesis mTOR signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton TNF signaling pathway Vascular smooth muscle contraction Apoptosis Autophagy Cellular senescence MAPK Erk pathway Ras signaling pathway Signaling pathways regulating pluripotency of stem cells B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Natural killer cell mediated cytotoxicity Osteoclast differentiation T cell receptor signaling pathway Toll-like receptor signaling pathway Apelin signaling pathway cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway Rap1 signaling pathway Sphingolipid signaling pathway Excitatory synapse pathway Neurotrophin signaling pathway
Protein Families Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Tissue Specificity Widely expressed, with extremely low levels in brain.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Format Liquid
Purification Antigen affinity purification
Purity Antigen affinity purification
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Applications ELISA, WB, IHC
Description ELISA ; WB ; IHC, WB ; ELISA ; IHC
Dilution

ELISA1:2000-1:5000
WB1:500-1:2000
IHC1:25-1:100
Tested Application ELISA,WB,IHC;ELISA:1:2000-1:5000,WB:1:500-1:2000,IHC:1:25-1:100
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
SKU Supplier No. Size Your price Quantity
BHA10554867 CSB-PA570222 100ul $299
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BHA10554867 CSB-PA570222 50ul $166
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