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Home / Primary Antibodies / IHC Antibodies

LRAT Antibody

SKU : BHA10559802

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA295134
Alternative Names	Lecithin retinol acyltransferase; EC 2.3.1.135; Phosphatidylcholine--retinol O-acyltransferase; LRAT;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.Ruiz A., J. Biol. Chem. 274:3834-3841(1999).Mondal M.S., Biochemistry 39:5215-5220(2000).Thompson D.A., Nat. Genet. 28:123-124(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human LRAT.
Involvement In Disease	Leber congenital amaurosis 14 (LCA14)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Ruiz A., J. Biol. Chem. 274:3834-3841(1999). Mondal M.S., Biochemistry 39:5215-5220(2000). Thompson D.A., Nat. Genet. 28:123-124(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total LRAT protein.
Subcellular Location	Endoplasmic reticulum membrane, Single-pass membrane protein, Rough endoplasmic reticulum, Endosome, multivesicular body, Cytoplasm, perinuclear region

Uniprot	O95237
Database Links	HGNC:6685 OMIM:604863 KEGG:hsa:9227 STRING:9606.ENSP00000337224 UniGene:Hs.658427
Function	Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
Protein Families	H-rev107 family
Tissue Specificity	Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559802	CSB-PA295134	100ul	$297		Add to Cart

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