Keratin type I cytoskeletal 20; Cytokeratin-20; CK-20; K20;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine By similarity.Qin Zhou, Mol. Biol. Cell, Jul 2003; 14: 2959.Qin Zhou, J. Biol. Chem., Jun 2006; 281: 16453 - 16461.F Smedts, Am. J. Pathol., Feb 1993; 142: 403.RK Miller, J. Cell Biol., May 1991; 113: 843.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Keratin 20.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine By similarity.
Qin Zhou, Mol. Biol. Cell, Jul 2003; 14: 2959. Qin Zhou, J. Biol. Chem., Jun 2006; 281: 16453 - 16461. F Smedts, Am. J. Pathol., Feb 1993; 142: 403. RK Miller, J. Cell Biol., May 1991; 113: 843.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Keratin 20 protein.
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
Pathway
Estrogen signaling pathway
Protein Families
Intermediate filament family
Tissue Specificity
Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of t
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.