Keratin type I cytoskeletal 16; Cytokeratin-16; CK-16; K16;
Antigen
KRT16
Categories
Primary Antibodies
Clonality
polyclonal
Description
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.Qian Wang, J. Virol., Jan 2004; 78: 821 - 833. RD Paladini, RD Paladini, J. Cell Biol., Feb 1996; 132: 381.M.K. Shamsher, Hum. Mol. Genet., Oct 1995; 4: 1875 - 1881.Ying-Nai Wang, Mol. Pharmacol., Jan 2006; 69: 85 - 98.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Keratin 16.
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Qian Wang, J. Virol., Jan 2004; 78: 821 - 833. RD Paladini, RD Paladini, J. Cell Biol., Feb 1996; 132: 381. M.K. Shamsher, Hum. Mol. Genet., Oct 1995; 4: 1875 - 1881. Ying-Nai Wang, Mol. Pharmacol., Jan 2006; 69: 85 - 98.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Keratin 16 protein.
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach
Pathway
Estrogen signaling pathway
Protein Families
Intermediate filament family
Tissue Specificity
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.