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Home / Primary Antibodies / IHC Antibodies

KANK2 Antibody

SKU : BHA10559456

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA178754
Alternative Names	Ankyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.Nagase T., DNA Res. 7:143-150(2000).Ota T., Nat. Genet. 36:40-45(2004).Olsen J.V., Cell 127:635-648(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human KANK2.
Involvement In Disease	Palmoplantar keratoderma and woolly hair (PPKWH)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation. Nagase T., DNA Res. 7:143-150(2000). Ota T., Nat. Genet. 36:40-45(2004). Olsen J.V., Cell 127:635-648(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KANK2 protein.
Subcellular Location	Cytoplasm, Mitochondrion

Uniprot	Q63ZY3
Database Links	HGNC:29300 OMIM:614610 KEGG:hsa:25959 STRING:9606.ENSP00000395650 UniGene:Hs.284208
Function	Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway
Tissue Specificity	Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,IHC,IF;IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559456	CSB-PA178754	100ul	$297		Add to Cart

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