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Home / Primary Antibodies / IHC Antibodies

JUP Antibody

SKU : BHA10559711

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA846873
Alternative Names	CTNNG; DP3; Desmoplakin III; JUP; Junction plakoglobin
Categories	Primary Antibodies
Clonality	polyclonal
Description	Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.T Naka, J. Clin. Pathol., Dec 2001; 54: 945 - 950.AR Burns, J. Immunol., Sep 1997; 159: 2893.Frank T. Kolligs, Genes & Dev., Jun 2000; 14: 1319.Jon A. Ukropec, J. Biol. Chem., Feb 2000; 275: 5983.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Catenin-γ.
Involvement In Disease	Naxos disease (NXD); Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity. T Naka, J. Clin. Pathol., Dec 2001; 54: 945 - 950. AR Burns, J. Immunol., Sep 1997; 159: 2893. Frank T. Kolligs, Genes & Dev., Jun 2000; 14: 1319. Jon A. Ukropec, J. Biol. Chem., Feb 2000; 275: 5983.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Catenin-γ protein.
Subcellular Location	Cell junction, adherens junction, Cell junction, desmosome, Cytoplasm, cytoskeleton, Membrane, Peripheral membrane protein

Uniprot	P14923
Database Links	HGNC:6207 OMIM:173325 KEGG:hsa:3728 STRING:9606.ENSP00000311113 UniGene:Hs.514174
Function	Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Protein Families	Beta-catenin family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559711	CSB-PA846873	100ul	$297		Add to Cart

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