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Home / Primary Antibodies / IHC Antibodies

IL23R Antibody

BHA10557240
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Email
[email protected]
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Rgd 1586368
Target Details This protein is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Uniprot Q5VWK5
Database Links

HGNC:19100

OMIM:607562

KEGG:hsa:149233

STRING:9606.ENSP00000321345

UniGene:Hs.677426
Function Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Pathway Jak-STAT signaling pathway Th17 cell differentiation
Protein Families Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format liquid
Purification >95%,Protein G purified
Purity Affinity purification
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Applications ELISA, WB, IHC
Description ELISA ; WB ; IHC, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:50-1:200
Tested Application ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
SKU Supplier No. Size Your price Quantity
BHA10557240 CSB-PA011639KA01HU 100ul $398
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