Molecular chaperone. Has ATPase activity. Ingrid K. Ruf, et,al. (2005) J. Virol 79: 14562 - 14569.Christy M. Hebner,et,al. (2006) J. Gen. Virol 87: 3183 - 3193.Rika van Huizen, et,al. (2003) J. Biol. Chem 278: 15558 - 15564.
Host
Rabbit
Immunogen
Peptide sequence around aa. 252~256 (V-G-S-D-E) derived from Human HSP90B.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Molecular chaperone. Has ATPase activity.
Ingrid K. Ruf, et,al. (2005) J. Virol ; 79: 14562 - 14569. Christy M. Hebner,et,al. (2006) J. Gen. Virol ; 87: 3183 - 3193. Rika van Huizen, et,al. (2003) J. Biol. Chem ; 278: 15558 - 15564.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total HSP90B protein.
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function
Pathway
Estrogen signaling pathway PI3K-Akt signaling pathway Necroptosis Protein processing in endoplasmic reticulum Antigen processing and presentation IL-17 signaling pathway NOD-like receptor signaling pathway Th17 cell differentiation
Protein Families
Heat shock protein 90 family
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.