Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.Koivisto L, et al. (2003) J Cell Sci. 116(Pt 18): 3749-3760.Welsh G I, et al. (1996) Trends Cell Biol. 6:274-279.Srivastava A K, et al. (1998) Mol. Cell. Biochem. 182: 135-141.Cross D A, et al. (1995) Nature. 378: 785-789.
Host
Rabbit
Immunogen
Peptide sequence around aa.19~23 (T-S-S-F-A) derived from Human GSK3a.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN
Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178. Koivisto L, et al. (2003) J Cell Sci. 116(Pt 18): 3749-3760. Welsh G I, et al. (1996) Trends Cell Biol. 6:274-279. Srivastava A K, et al. (1998) Mol. Cell. Biochem. 182: 135-141. Cross D A, et al. (1995) Nature. 378: 785-789.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total GSK3a protein. and does not detect GSK-3b protein.
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Pathway
Chemokine signaling pathway
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.