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Home / Primary Antibodies / IHC Antibodies

GRM6 Antibody

SKU : BHA10559740

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA180398
Alternative Names	EAA4; GLR6; MGC74427; bA487F5.1 (glutamate receptor; ionotropic
Categories	Primary Antibodies
Clonality	polyclonal
Description	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity. Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.Inga Everts, J. Neurosci., Feb 1999; 19: 916.Gregory D. Salinas, J. Biol. Chem., Dec 2006; 281: 40164 - 40173.Sheng Yan, J. Neurosci., Jan 2004; 24: 679.Xiao-Mei Liu, J. Biol. Chem., Jun 2006; 281: 17432 - 17445.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human GluR6.
Involvement In Disease	Night blindness, congenital stationary, 1B (CSNB1B)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity. Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision. Inga Everts, J. Neurosci., Feb 1999; 19: 916. Gregory D. Salinas, J. Biol. Chem., Dec 2006; 281: 40164 - 40173. Sheng Yan, J. Neurosci., Jan 2004; 24: 679. Xiao-Mei Liu, J. Biol. Chem., Jun 2006; 281: 17432 - 17445.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GluR6 protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein, Cell projection, dendrite

Uniprot	O15303
Database Links	HGNC:4598 OMIM:257270 KEGG:hsa:2916 STRING:9606.ENSP00000231188 UniGene:Hs.248131
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Pathway	Oxidative Phosphorylation Phospholipase D signaling pathway Glutamatergic synapse
Protein Families	G-protein coupled receptor 3 family
Tissue Specificity	Detected in melanocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559740	CSB-PA180398	100ul	$297		Add to Cart

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