adenylate cyclase-stimulating G alpha protein; olfactory type; guanine nucleotide-binding protein G(olf) alpha;
Antigen
GNAL
Categories
Primary Antibodies
Clonality
polyclonal
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.Zigman J.M., Endocrinology 133:2508-2514(1993).Vuoristo J.T., Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.Puhl H.L. III, Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human GNAL.
Involvement In Disease
Dystonia 25 (DYT25)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
Zigman J.M., Endocrinology 133:2508-2514(1993). Vuoristo J.T., Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. Puhl H.L. III, Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total GNAL protein.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
Pathway
Calcium signaling pathway
Protein Families
G-alpha family, G(s) subfamily
Tissue Specificity
Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.