Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.Ishibashi Y., Glycoconj. J. 22:53-62(2005).Huang M.-C., Oncogene 25:3267-3276(2006).Tan S., Am. J. Respir. Cell Mol. Biol. 36:737-745(2007).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human GCNT3.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
Ishibashi Y., Glycoconj. J. 22:53-62(2005). Huang M.-C., Oncogene 25:3267-3276(2006). Tan S., Am. J. Respir. Cell Mol. Biol. 36:737-745(2007).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total GCNT3 protein.
Subcellular Location
Golgi apparatus membrane, Single-pass type II membrane protein
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
Protein Families
Glycosyltransferase 14 family
Tissue Specificity
Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.