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Home / Primary Antibodies / IHC Antibodies

GATA1 (Ab-142) Antibody

SKU : BHA10559616

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA440674
Alternative Names	GAT1; GATA1; GF-1; NF-E1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.Zon LI, et al. (1990) Proc Natl Acad. Sci USA. 87: 668-672.Trainor C D, et al. (1990) Nature. 343: 92-96.Nichols K E, et al. (2000) Nat Genet. 24: 266-270.Freson K, et al. (2001) Blood. 98: 85-92.Mehaffey M G, et al. (2001) Blood. 98: 2681-2688.
Host	Rabbit
Immunogen	Peptide sequence around aa.140~144 (R-L-S-P-D) derived from Human GATA1.
Involvement In Disease	X-linked dyserythropoietic anemia and thrombocytopenia (XDAT); Thrombocytopenia with beta-thalassemia, X-linked (XLTT); Anemia without thrombocytopenia, X-linked (XLAWT)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Zon LI, et al. (1990) Proc Natl Acad. Sci USA. 87: 668-672. Trainor C D, et al. (1990) Nature. 343: 92-96. Nichols K E, et al. (2000) Nat Genet. 24: 266-270. Freson K, et al. (2001) Blood. 98: 85-92. Mehaffey M G, et al. (2001) Blood. 98: 2681-2688.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total GATA1 protein.
Subcellular Location	Nucleus

Uniprot	P15976
Database Links	HGNC:4170 OMIM:300367 KEGG:hsa:2623 STRING:9606.ENSP00000365858 UniGene:Hs.765
Function	Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS
Tissue Specificity	Erythrocytes.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559616	CSB-PA440674	100ul	$297		Add to Cart

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