B-50; BASP2; NEUM; PP46; axonal membrane protein GAP-43
Antigen
GAP43
Categories
Primary Antibodies
Clonality
polyclonal
Description
GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Rachael L. Neve, et,al. (1998) J. Neurosci; 18: 7757. Yiping Shen, et,al. (2002) J. Neurosci; 22: 239.Chantal Gamby, et,al. (1996) J. Biol. Chem; 271: 26698.
Host
Rabbit
Immunogen
Peptide sequence around aa.38~43 (Q-A-S-F-R) derived from Human GAP43.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Rachael L. Neve, et,al. (1998) J. Neurosci; 18: 7757. Yiping Shen, et,al. (2002) J. Neurosci; 22: 239. Chantal Gamby, et,al. (1996) J. Biol. Chem; 271: 26698.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total GAP43 protein.
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Protein Families
Neuromodulin family
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.