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Home / Primary Antibodies / IHC Antibodies

GAD2 Antibody

SKU : BHA10559181

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA258867
Alternative Names	Glutamate decarboxylase 2; EC 4.1.1.15; Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.JB Travers, Chem Senses, Feb 2007; 32: 129 - 137.Rita Sulahian, Nucleic Acids Res., Mar 2006; 34: 1351 - 1357.Andrea Pillai, Development, Jan 2007; 134: 357 - 366.Dmytro P. Yevtushenko, J. Exp. Bot., Aug 2003; 54: 2001 - 2002.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human GAD1/GAD2.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. JB Travers, Chem Senses, Feb 2007; 32: 129 - 137. Rita Sulahian, Nucleic Acids Res., Mar 2006; 34: 1351 - 1357. Andrea Pillai, Development, Jan 2007; 134: 357 - 366. Dmytro P. Yevtushenko, J. Exp. Bot., Aug 2003; 54: 2001 - 2002.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GAD1/GAD2 protein.

Uniprot	Q4G154

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559181	CSB-PA258867	100ul	$297		Add to Cart

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