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Home / Primary Antibodies / IHC Antibodies

FRK Antibody

SKU : BHA10559815

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA237384
Alternative Names	EC 2.7.1.112; EC 2.7.10.2; Nuclear tyrosine protein kinase RAK; Tyrosine-protein kinase FRK; fyn-related kinase
Categories	Primary Antibodies
Clonality	polyclonal
Description	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in tu prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.Lee J., Gene 138:247-251(1994).Cance W.G., Cell Growth Differ. 5:1347-1355(1994).Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).
Host	Rabbit
Immunogen	Synthesized peptide derived from inteal of Human FRK.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in tu prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. Lee J., Gene 138:247-251(1994). Cance W.G., Cell Growth Differ. 5:1347-1355(1994). Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FRK protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P42685
Database Links	HGNC:3955 OMIM:606573 KEGG:hsa:2444 STRING:9606.ENSP00000357615 UniGene:Hs.89426
Function	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in tu prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Protein Families	Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
Tissue Specificity	Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559815	CSB-PA237384	100ul	$297		Add to Cart

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