Tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; Fas ligand; CD178 antigen; CD95L protein
Antigen
FASLG
Categories
Primary Antibodies
Clonality
polyclonal
Description
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.Alderson M.; J. Exp. Med. 181:71-77(1995).Takahashi T., Int. Immunol. 6:1567-1574(1994).Gregory S.G., ure 441:315-321(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human FAS ligand.
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.
Alderson M.; J. Exp. Med. 181:71-77(1995). Takahashi T., Int. Immunol. 6:1567-1574(1994). Gregory S.G., ure 441:315-321(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total FAS ligand protein.
Subcellular Location
Cell membrane, Single-pass type II membrane protein, Cytoplasmic vesicle lumen, Lysosome lumen, Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290), Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115), SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted, Note=May be released into the extracellular fluid by cleavage from the cell surface, SUBCELLULAR LOCATION: FasL intracellular domain: Nucleus