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Home / Primary Antibodies / IHC Antibodies

FAS Antibody

SKU : BHA10559216

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA942791
Alternative Names	Apo-1; CD95; FasL receptor; TNFRSF6; TNR6
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).Michael J. Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000; 278: 354. Morgan Jenkins, J. Immunol., Aug 1999; 163: 1195. Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999; 91: 1678 - 1684. JOS E. CARDIER, FASEB J, Nov 1999; 13: 1950.
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human Fas.
Involvement In Disease	Autoimmune lymphoproliferative syndrome 1A (ALPS1A)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Michael J. Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000; 278: 354. Morgan Jenkins, J. Immunol., Aug 1999; 163: 1195. Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999; 91: 1678 - 1684. JOS? E. CARDIER, FASEB J, Nov 1999; 13: 1950.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Fas protein.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Isoform 3: Secreted, SUBCELLULAR LOCATION: Isoform 4: Secreted, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform 6: Secreted

Uniprot	P25445
Database Links	HGNC:11920 OMIM:134637 KEGG:hsa:355 STRING:9606.ENSP00000347979 UniGene:Hs.244139
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Pathway	MAPK signaling pathway p53 signaling pathway TNF signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity
Tissue Specificity	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559216	CSB-PA942791	100ul	$297		Add to Cart

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