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Home / Primary Antibodies / IHC Antibodies

ERCC1 Antibody

SKU : BHA10559725

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA827559
Alternative Names	UV20; DNA REPAIR DEFECT UV-20 OF CHINESE HAMSTER OVARY CELLS; COMPLEMENTATION OF EXCISION-REPAIR; COMPLEMENTING DEFECTIVE IN CHINESE HAMSTER; excision repair cross-complementing 1 isoform 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.Kan-Tai Hsia, Development, Jan 2003; 130: 369.Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550.Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857.Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human ERCC1.
Involvement In Disease	Cerebro-oculo-facio-skeletal syndrome 4 (COFS4)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Kan-Tai Hsia, Development, Jan 2003; 130: 369. Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550. Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857. Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ERCC1 protein.
Subcellular Location	Isoform 1: Nucleus, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, Nucleus, SUBCELLULAR LOCATION: Isoform 3: Nucleus, SUBCELLULAR LOCATION: Isoform 4: Nucleus

Uniprot	P07992
Database Links	HGNC:3433 OMIM:126380 KEGG:hsa:2067 STRING:9606.ENSP00000013807 UniGene:Hs.435981
Function	Isoform 1
Pathway	DNA repair pathway
Protein Families	ERCC1/RAD10/SWI10 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559725	CSB-PA827559	100ul	$297		Add to Cart

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