UV20; DNA REPAIR DEFECT UV-20 OF CHINESE HAMSTER OVARY CELLS; COMPLEMENTATION OF EXCISION-REPAIR; COMPLEMENTING DEFECTIVE IN CHINESE HAMSTER; excision repair cross-complementing 1 isoform 1
Antigen
ERCC1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.Kan-Tai Hsia, Development, Jan 2003; 130: 369.Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550.Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857.Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human ERCC1.
Involvement In Disease
Cerebro-oculo-facio-skeletal syndrome 4 (COFS4)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Kan-Tai Hsia, Development, Jan 2003; 130: 369. Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550. Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857. Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ERCC1 protein.