Elongation of very long chain fatty acids protein 5; ELOV5; ELOVL2; hELO1;
Antigen
ELOVL5
Categories
Primary Antibodies
Clonality
polyclonal
Description
Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA.Leonard A.E., Biochem. J. 350:765-770(2000).Suzuki T., Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.Wiemann S., Genome Res. 11:422-435(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ELOVL5.
Involvement In Disease
Spinocerebellar ataxia 38 (SCA38)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA.
Leonard A.E., Biochem. J. 350:765-770(2000). Suzuki T., Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. Wiemann S., Genome Res. 11:422-435(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ELOVL5 protein.
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18
Protein Families
ELO family, ELOVL5 subfamily
Tissue Specificity
Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.