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Home / Primary Antibodies / IHC Antibodies

EIF4EBP1 (Ab-69) Antibody

SKU : BHA10559101

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA936560
Alternative Names	4EBP1; EIF4EBP1; P/OKCL.6; PHAS-1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.Anne-Claude Gingras, Genes & Dev., Jun 1999; 13: 1422. Guangming Liu, J. Biol. Chem., Mar 2002; 277: 8810 - 8816. Ya-Ping Jiang, J. Biol. Chem., Mar 2001; 276: 10943 - 10951. Anne-Claude Gingras, Genes & Dev., Feb 1998; 12: 502.
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human 4E-BP1 around the phosphorylation site of threonine 70 (A-K-T-P-P).
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Anne-Claude Gingras, Genes & Dev., Jun 1999; 13: 1422. Guangming Liu, J. Biol. Chem., Mar 2002; 277: 8810 - 8816. Ya-Ping Jiang, J. Biol. Chem., Mar 2001; 276: 10943 - 10951. Anne-Claude Gingras, Genes & Dev., Feb 1998; 12: 502.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total 4E-BP1 protein.

Uniprot	Q13541
Database Links	HGNC:3288 OMIM:602223 KEGG:hsa:1978 STRING:9606.ENSP00000340691 UniGene:Hs.411641
Function	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex
Pathway	ErbB signaling pathway HIF-1 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Cellular senescence AMPK signaling Insulin signaling pathway
Protein Families	EIF4E-binding protein family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559101	CSB-PA936560	100ul	$297		Add to Cart

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