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Home / Primary Antibodies / IHC Antibodies

EIF4E (Ab-209) Antibody

SKU : BHA10559647

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA190338
Alternative Names	mRNA cap-binding protein; eIF-4F 25 kDa subunit;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.Li BD, et al. (1998) Ann Surg; 227(5): 756-763Altmann M, et al. (1989) Nucleic Acids Res; 17(18): 7520De Gregorio E, et al. (2001) RNA; 7(1): 106-113Gu W, et al. (2004) Nucleic Acids Res; 32(15): 4448-4461Ohlmann T, et al. (1996) EMBO J; 15(6): 1371-1382
Host	Rabbit
Immunogen	Peptide sequence around aa. 207~211 (S-G-S-T-T) derived from Human eIF4E.
Involvement In Disease	Autism 19 (AUTS19)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Li BD, et al. (1998) Ann Surg; 227(5): 756-763 Altmann M, et al. (1989) Nucleic Acids Res; 17(18): 7520 De Gregorio E, et al. (2001) RNA; 7(1): 106-113 Gu W, et al. (2004) Nucleic Acids Res; 32(15): 4448-4461 Ohlmann T, et al. (1996) EMBO J; 15(6): 1371-1382
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total elF4E protein.
Subcellular Location	Cytoplasm, P-body, Cytoplasm

Uniprot	P06730
Database Links	HGNC:3287 OMIM:133440 KEGG:hsa:1977 UniGene:Hs.13211
Function	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Pathway	HIF-1 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Insulin signaling pathway
Protein Families	Eukaryotic initiation factor 4E family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559647	CSB-PA190338	100ul	$297		Add to Cart

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