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Home / Primary Antibodies / IHC Antibodies

EGFR (Ab-1092) Antibody

SKU : BHA10558973

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA953009
Alternative Names	Receptor tyrosine-protein kinase ErbB-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiaBuerger C, et al. (2003) J Biol Chem; 278(39): 37610-21.Wang XQ, (2003) J Biol Chem; 278(49): 48770-8.Saito T, et al. (2004) Endocrinology; 145(9): 4232-43.Pao W, et al. (2004) Proc Natl Acad Sci U S A; 101(36): 13306-11.Mattila E, et al. (2005) Nat Cell Biol; 7(1): 78-85.
Host	Rabbit
Immunogen	Peptide sequence around aa. 1090~1094 (P-E-Y-I-N) derived from Human EGFR.
Involvement In Disease	Lung cancer (LNCR); Inflammatory skin and bowel disease, neonatal, 2 (NISBD2)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentia Buerger C, et al. (2003) J Biol Chem; 278(39): 37610-21. Wang XQ, (2003) J Biol Chem; 278(49): 48770-8. Saito T, et al. (2004) Endocrinology; 145(9): 4232-43. Pao W, et al. (2004) Proc Natl Acad Sci U S A; 101(36): 13306-11. Mattila E, et al. (2005) Nat Cell Biol; 7(1): 78-85.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total EGFR protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Nucleus membrane, Single-pass type I membrane protein, Endosome, Endosome membrane, Nucleus

Uniprot	P00533
Database Links	HGNC:3236 OMIM:131550 KEGG:hsa:1956 STRING:9606.ENSP00000275493 UniGene:Hs.488293
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
Pathway	Calcium signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Adherens junction Ras signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway Endocytosis
Protein Families	Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558973	CSB-PA953009	100ul	$297		Add to Cart

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