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Home / Primary Antibodies / IHC Antibodies

DNMT3B Antibody

SKU : BHA10559916

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA593881
Alternative Names	DNA (cytosine-5)-methyltransferase 3B; EC 2.1.1.37; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.Deloukas P., Nature 414:865-871(2001).Li H., J. Biol. Chem. 281:19489-19500(2006).Wijmenga C., Hum. Mutat. 16:509-517(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human DNMT3B.
Involvement In Disease	Immunodeficiency-centromeric instability-facial anomalies syndrome 1 (ICF1); Facioscapulohumeral muscular dystrophy 2 (FSHD2)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Deloukas P., Nature 414:865-871(2001). Li H., J. Biol. Chem. 281:19489-19500(2006). Wijmenga C., Hum. Mutat. 16:509-517(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DNMT3B protein.
Subcellular Location	Nucleus

Uniprot	Q9UBC3
Database Links	HGNC:2979 OMIM:158901 KEGG:hsa:1789 STRING:9606.ENSP00000328547 UniGene:Hs.643024
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells
Protein Families	Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Tissue Specificity	Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, s

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559916	CSB-PA593881	100ul	$297		Add to Cart

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