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Home / Primary Antibodies / IHC Antibodies

DLC1 Antibody

SKU : BHA10559352

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA124374
Alternative Names	Rho-type GTPase-activating protein 7; Deleted in liver cancer 1 protein; Dlc-1; HP protein; StAR-related lipid transfer protein 12
Categories	Primary Antibodies
Clonality	polyclonal
Description	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.Yuan B.Z., Cancer Res. 58:2196-2199(1998).Nagase T., DNA Res. 7:347-355(2000).Wilson P.J., Hum. Mutat. 15:156-165(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human RHG07.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Yuan B.Z., Cancer Res. 58:2196-2199(1998). Nagase T., DNA Res. 7:347-355(2000). Wilson P.J., Hum. Mutat. 15:156-165(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total RHG07 protein.
Subcellular Location	Cytoplasm, Cell junction, focal adhesion, Membrane, Peripheral membrane protein

Uniprot	Q96QB1
Database Links	HGNC:2897 OMIM:604258 KEGG:hsa:10395 STRING:9606.ENSP00000276297 UniGene:Hs.134296
Function	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
Tissue Specificity	Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,IHC,IF;IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559352	CSB-PA124374	100ul	$297		Add to Cart

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