AI043103; AI790593; D14Ucla2; dehydrogenase/reductase (SDR family) member 4; EC 1.1.1.184
Categories
Primary Antibodies
Clonality
polyclonal
Description
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones By similarity.Fransen M., Biochem. J. 340:561-568(1999).Furukawa A., Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.Du J., Yi Chuan Xue Bao 31:661-667(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human DHRS4.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones By similarity.
Fransen M., Biochem. J. 340:561-568(1999). Furukawa A., Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. Du J., Yi Chuan Xue Bao 31:661-667(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total DHRS4 protein.
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity
Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.