Cytochrome P450; family 8; subfamily B; polypeptide 1; CYP8B1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.Gaafvels M., Genomics 56:184-196(1999).Ota T., Nat. Genet. 36:40-45(2004).Muzny D.M., Nature 440:1194-1198(2006)
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human Cytochrome P450 8B1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
Gaafvels M., Genomics 56:184-196(1999). Ota T., Nat. Genet. 36:40-45(2004). Muzny D.M., Nature 440:1194-1198(2006)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Cytochrome P450 8B1 protein.
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
Pathway
PPAR signaling pathway
Protein Families
Cytochrome P450 family
Tissue Specificity
Liver.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.