The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development.Zhang Z., Protein Sci. 13:2819-2824(2004).Deloukas P., Nature 414:865-871(2001).Clark H.F., Genome Res. 13:2265-2270(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CST9L.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development.
Zhang Z., Protein Sci. 13:2819-2824(2004). Deloukas P., Nature 414:865-871(2001). Clark H.F., Genome Res. 13:2265-2270(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CST9L protein.