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Home / Primary Antibodies / IHC Antibodies

CSNK1E Antibody

SKU : BHA10559915

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA907561
Alternative Names	CK1-epsilon; CKI-epsilon; CKIe; CSNK1E; Casein kinase I
Categories	Primary Antibodies
Clonality	polyclonal
Description	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.Fish K.J., J. Biol. Chem. 270:14875-14883(1995).Okamura A., Blood 103:2997-3004(2004).Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CKI-ε.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Fish K.J., J. Biol. Chem. 270:14875-14883(1995). Okamura A., Blood 103:2997-3004(2004). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CKI-ε protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P49674
Database Links	HGNC:2453 OMIM:600863 KEGG:hsa:102800317 STRING:9606.ENSP00000352929 UniGene:Hs.474833
Function	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Protein Families	Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Tissue Specificity	Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559915	CSB-PA907561	100ul	$297		Add to Cart

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