Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 - 5340.Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 - 55681.Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051.Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19
Host
Rabbit
Immunogen
Synthesized peptide derived from Human CREB-BP.
Involvement In Disease
Rubinstein-Taybi syndrome 1 (RSTS1)
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 - 5340. Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 - 55681. Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051. Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CREB-BP protein.
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators