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Home / Primary Antibodies / IHC Antibodies

CREBBP Antibody

SKU : BHA10557385

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA027631
Alternative Names	CBP; CREB binding protein; CREB-binding protein; CREBBP; KAT3A; RSTS
Categories	Primary Antibodies
Clonality	polyclonal
Description	CBP a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; "
Host	Rabbit
Immunogen	A synthesized peptide derived from Human CBP
Involvement In Disease	Rubinstein-Taybi syndrome 1 (RSTS1)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	CBP a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; "
Species	Homo Sapiens (Human)
Specificity	CBP Antibody detects endogenous levels of CBP
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q92793
Database Links	HGNC:2348 OMIM:180849 KEGG:hsa:1387 STRING:9606.ENSP00000262367 UniGene:Hs.459759
Function	Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators
Pathway	cAMP signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway Melanogenesis Notch signaling pathway TGF-beta signaling pathway Wnt signaling pathway Adherens junction Cell cycle FoxO signaling pathway Glucagon signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF, ICC

Description

ELISA ; WB ; IHC ; IF ; ICC, ICC ; ELISA ; IHC ; WB ; IF

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
IF	1:100-1:500
ICC	1:100-1:500

Tested Application

ELISA,WB,IHC,IF/ICC;WB:1:500-1:2000,IHC:1:50-1:200,IF/ICC:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557385	CSB-PA027631	100ul	$295		Add to Cart

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