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Home / Primary Antibodies / IHC Antibodies

COL4A1 Antibody

SKU : BHA10559172

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA975386
Alternative Names	COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide
Categories	Primary Antibodies
Clonality	polyclonal
Description	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802.Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171.PJ Lein, J. Cell Biol., Apr 1991; 113: 417.EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Collagen IV.
Involvement In Disease	Brain small vessel disease with or without ocular anomalies (BSVD); Hereditary angiopathy with nephropathy aneurysms and muscle cramps (HANAC); Porencephaly 1 (POREN1); Intracerebral hemorrhage (ICH); Tortuosity of retinal arteries (RATOR); Schizencephaly (SCHZC)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802. Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171. PJ Lein, J. Cell Biol., Apr 1991; 113: 417. EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Collagen IV protein.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane

Uniprot	P02462
Gene Id	1282
Database Links	HGNC:2202 OMIM:120130 KEGG:hsa:1282 STRING:9606.ENSP00000364979 UniGene:Hs.17441
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Pathway	PI3K-Akt signaling pathway Focal adhesion AGE-RAGE signaling pathway in diabetic complications
Protein Families	Type IV collagen family
Tissue Specificity	Highly expressed in placenta.
Weight	127,981 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559172	CSB-PA975386	100ul	$297		Add to Cart

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