chondrocalcin; CO2A1; collagen alpha-1 (II); collagen type II alpha 1;
Antigen
COL2A1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.Seema K. Tiwari-Woodruff, J. Cell Biol., Apr 2001; 153: 295.Alexander Gow, J. Neurosci., Aug 2004; 24: 7051 - 7062.Anne Florin, Endocrinology, Mar 2005; 146: 1532 - 1540.Shin-ichiro Kitajiri, J. Cell Sci., Oct 2004; 117: 5087 - 5096.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Collagen II.
Involvement In Disease
Spondyloepiphyseal dysplasia congenital type (SEDC); Spondyloepiphyseal dysplasia, Stanescu type (SEDSTN); Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK); Achondrogenesis 2 (ACG2); Legg-Calve-Perthes disease (LCPD); Kniest dysplasia (KD); Avascular necrosis of femoral head, primary, 1 (ANFH1); Osteoarthritis with mild chondrodysplasia (OSCDP); Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T); Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD); Spondyloperipheral dysplasia (SPD); Stickler syndrome 1 (STL1); Stickler syndrome 1 non-syndromic ocular (STL1O); Rhegmatogenous retinal detachment autosomal dominant (DRRD); Czech dysplasia (CZECHD)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Seema K. Tiwari-Woodruff, J. Cell Biol., Apr 2001; 153: 295. Alexander Gow, J. Neurosci., Aug 2004; 24: 7051 - 7062. Anne Florin, Endocrinology, Mar 2005; 146: 1532 - 1540. Shin-ichiro Kitajiri, J. Cell Sci., Oct 2004; 117: 5087 - 5096.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Collagen II protein.
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Pathway
PI3K-Akt signaling pathway Focal adhesion
Protein Families
Fibrillar collagen family
Tissue Specificity
Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.
Weight
141,785 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.