Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.Hiroshi Honda and Patrice J. Morin, AACR Meeting Abstracts, Apr 2006; 2006: 208
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Claudin 3.
Involvement In Disease
CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.
Hiroshi Honda and Patrice J. Morin, AACR Meeting Abstracts, Apr 2006; 2006: 208
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Claudin 3 protein.
Subcellular Location
Cell junction, tight junction, Cell membrane, Multi-pass membrane protein