centrosomal protein 152 kDa; centrosomal protein 152kDa; centrosomal protein of 152 kDa;
Antigen
CEP152
Categories
Primary Antibodies
Clonality
polyclonal
Description
Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.Nagase T., DNA Res. 5:355-364(1998).The MGC Project Team; Genome Res. 14:2121-2127(2004).Andersen J.S., Nature 426:570-574(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CEP152.
Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.
Nagase T., DNA Res. 5:355-364(1998). The MGC Project Team; Genome Res. 14:2121-2127(2004). Andersen J.S., Nature 426:570-574(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CEP152 protein.
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication
Protein Families
CEP152 family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.