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Home / Primary Antibodies / IHC Antibodies

CEP152 Antibody

SKU : BHA10558325

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA042364
Alternative Names	centrosomal protein 152 kDa; centrosomal protein 152kDa; centrosomal protein of 152 kDa;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.Nagase T., DNA Res. 5:355-364(1998).The MGC Project Team; Genome Res. 14:2121-2127(2004).Andersen J.S., Nature 426:570-574(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CEP152.
Involvement In Disease	Microcephaly 9, primary, autosomal recessive (MCPH9); Seckel syndrome 5 (SCKL5)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles. Nagase T., DNA Res. 5:355-364(1998). The MGC Project Team; Genome Res. 14:2121-2127(2004). Andersen J.S., Nature 426:570-574(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CEP152 protein.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole

Uniprot	O94986
Database Links	HGNC:29298 OMIM:613529 KEGG:hsa:22995 STRING:9606.ENSP00000382271 UniGene:Hs.443005
Function	Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication
Protein Families	CEP152 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558325	CSB-PA042364	100ul	$297		Add to Cart

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