5-azacytidine-induced 1; centrosomal protein of 131 kDa; Cep131; pre-acrosome localization 1;
Antigen
CEP131
Categories
Primary Antibodies
Clonality
polyclonal
Description
Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells.Kikuno R., DNA Res. 6:197-205(1999).Andersen J.S., Nature 426:570-574(2003).Olsen J.V., Cell 127:635-648(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human AZI1.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells.
Kikuno R., DNA Res. 6:197-205(1999). Andersen J.S., Nature 426:570-574(2003). Olsen J.V., Cell 127:635-648(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total AZI1 protein.