Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.Youzhong Yuan, Cancer Res., Jan 2006; 66: 343 - 351. A. Koenig, Vet. Pathol., Jul 2002; 39: 458. Pei-Fang Hung, Am J Physiol Cell Physiol, May 2005; 288: C1094 - C1108. Mana Mirjany, J. Pharmacol. Exp. Ther., May 2002; 301: 494.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human p18 INK antibody.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Youzhong Yuan, Cancer Res., Jan 2006; 66: 343 - 351. A. Koenig, Vet. Pathol., Jul 2002; 39: 458. Pei-Fang Hung, Am J Physiol Cell Physiol, May 2005; 288: C1094 - C1108. Mana Mirjany, J. Pharmacol. Exp. Ther., May 2002; 301: 494.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total p18 INK protein.
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Pathway
Cell cycle
Protein Families
CDKN2 cyclin-dependent kinase inhibitor family
Tissue Specificity
Highest levels found in skeletal muscle. Also found in pancreas and heart.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.