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Home / Primary Antibodies / IHC Antibodies

CDKN1B (Ab-10) Antibody

SKU : BHA10558999

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA018782
Alternative Names	CDKN1B; CDN1B; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; KIP1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.Le XF, et al. (2003)J Biol Chem.Connor MK, et al. (2003)Mol Biol Cell; 14(1): 201-13.McAllister SS, et al. (2003) Mol Cell Biol; 23(1): 216-28.Chopra S, et al. (2002)J Biol Chem; 277(36): 32413-6.Boehm M, et al. (2002)EMBO J; 21(13): 3390-401.
Host	Rabbit
Immunogen	Peptide sequence around aa.8~12 (N-G-S-P-S) derived from Human p27Kip1.
Involvement In Disease	Multiple endocrine neoplasia 4 (MEN4)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events. Le XF, et al. (2003)J Biol Chem. Connor MK, et al. (2003)Mol Biol Cell; 14(1): 201-13. McAllister SS, et al. (2003) Mol Cell Biol; 23(1): 216-28. Chopra S, et al. (2002)J Biol Chem; 277(36): 32413-6. Boehm M, et al. (2002)EMBO J; 21(13): 3390-401.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total p27Kip1 protein.
Subcellular Location	Nucleus, Cytoplasm, Endosome

Uniprot	P46527
Database Links	HGNC:1785 OMIM:600778 KEGG:hsa:1027 STRING:9606.ENSP00000228872 UniGene:Hs.238990
Function	Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA
Pathway	ErbB signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Cell cycle AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway
Protein Families	CDI family
Tissue Specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558999	CSB-PA018782	100ul	$297		Add to Cart

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