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Home / Primary Antibodies / IHC Antibodies

CDC42BPB Antibody

SKU : BHA10559374

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA936608
Alternative Names	CDC42-binding protein kinase beta; CDC42BPB; EC 2.7.11.1; MRCK-beta;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.Nakajima D., DNA Res. 9:99-106(2002).Olsen J.V., Cell 127:635-648(2006).Hirosawa M., DNA Res. 6:329-336(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MRCKB.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. Nakajima D., DNA Res. 9:99-106(2002). Olsen J.V., Cell 127:635-648(2006). Hirosawa M., DNA Res. 6:329-336(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MRCKB protein.
Subcellular Location	Cytoplasm, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell junction, Cell projection, lamellipodium

Uniprot	Q9Y5S2
Database Links	HGNC:1738 OMIM:614062 KEGG:hsa:9578 STRING:9606.ENSP00000355237 UniGene:Hs.654634
Function	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family, DMPK subfamily
Tissue Specificity	Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559374	CSB-PA936608	100ul	$297		Add to Cart

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