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Home / Primary Antibodies / IHC Antibodies

CASP7 Antibody

SKU : BHA10557220

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA004552KA01HU
Alternative Names	CMH-1; ICE-LAP3; MCH3; CASP7; Caspase-7
Categories	Primary Antibodies
Description	Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis . Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP. During apoptosis, caspase-7 is activated through proteolytic processsing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits. Similar to caspases-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD.
Hgnc	1508, 1508
Host	Rabbit
Immunogen	Recombinant protein of human CASP7
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Isotype	IgG
Mgi	109383
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis . Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP. During apoptosis, caspase-7 is activated through proteolytic processsing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits. Similar to caspases-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm

Rgd	620944
Target Details	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
Uniprot	P55210
Database Links	HGNC:1508 OMIM:601761 KEGG:hsa:840 STRING:9606.ENSP00000358327 UniGene:Hs.9216
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- ; -Gly-217' bond. Overexpression promotes programmed cell death.
Pathway	TNF signaling pathway Apoptosis, TNF signaling pathway Apoptosis
Protein Families	Peptidase C14A family
Research Area	Apoptosis
Tissue Specificity	Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557220	CSB-PA004552KA01HU	100μl	$387.33		Add to Cart

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