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Home / Primary Antibodies / IHC Antibodies

CASP10 Antibody

SKU : BHA10559889

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA072389
Alternative Names	ALPS2; CASP10B; FLICE2; Caspase 10 isoform a preproprotein; Caspase 10 isoform b preproprotein
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC. Isoform C is proteolytically inactive.Frank C. Kischkel, J. Biol. Chem., Nov 2001; 276: 46639 - 46646.Ingo H. Engels, Mol. Cell. Biol., Apr 2005; 25: 2808 - 2818.Daniela Sciaky, J. Immunol., Apr 2000; 164: 3806.Jin Wang, PNAS, Nov 2001; 98: 13884.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human Caspase 10.
Involvement In Disease	Autoimmune lymphoproliferative syndrome 2A (ALPS2A); Familial non-Hodgkin lymphoma (NHL); Gastric cancer (GASC)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- ; -AMC and Asp-Glu-Val-Asp- ; -AMC. Isoform C is proteolytically inactive. Frank C. Kischkel, J. Biol. Chem., Nov 2001; 276: 46639 - 46646. Ingo H. Engels, Mol. Cell. Biol., Apr 2005; 25: 2808 - 2818. Daniela Sciaky, J. Immunol., Apr 2000; 164: 3806. Jin Wang, PNAS, Nov 2001; 98: 13884.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Caspase 10 protein.

Uniprot	Q92851
Database Links	HGNC:1500 OMIM:601762 KEGG:hsa:843 STRING:9606.ENSP00000286186 UniGene:Hs.5353
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- ; -AMC and Asp-Glu-Val-Asp- ; -AMC.
Pathway	TNF signaling pathway Apoptosis
Protein Families	Peptidase C14A family
Tissue Specificity	Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559889	CSB-PA072389	100ul	$297		Add to Cart

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