JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / IHC Antibodies

BCL2 (Ab-70) Antibody

SKU : BHA10559618

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

CUSABIO TECHONOLOGY LLC

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	CSB-PA129411
Alternative Names	BCL2
Categories	Primary Antibodies
Clonality	polyclonal
Description	BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.Muller IM, et al. (2005) Mol Pharmacol.Jin Z, Gao F,et al. J Biol Chem 2004 Sep 17; 279(38): 40209-19.Kumar Biswas S,et al. Mol Cancer Ther 2004 Mar; 3(3): 327-34.Huang ST,et al. (2002)FASEB J; 16(8): 825-32.Yamamoto K,et al. (1999) Mol Cell Biol; 19(12): 8469-78.
Host	Rabbit
Immunogen	Peptide sequence around aa.68~72 (R-T-S-P-L) derived from Human BCL-2.
Involvement In Disease	A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. Muller IM, et al. (2005) Mol Pharmacol. Jin Z, Gao F,et al. J Biol Chem 2004 Sep 17; 279(38): 40209-19. Kumar Biswas S,et al. Mol Cancer Ther 2004 Mar; 3(3): 327-34. Huang ST,et al. (2002)FASEB J; 16(8): 825-32. Yamamoto K,et al. (1999) Mol Cell Biol; 19(12): 8469-78.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total BCL-2 protein.
Subcellular Location	Mitochondrion outer membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein

Uniprot	P10415
Gene Id	596
Database Links	HGNC:990 OMIM:151430 KEGG:hsa:596 STRING:9606.ENSP00000329623 UniGene:Hs.150749
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release
Pathway	Estrogen signaling pathway Hedgehog signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway PI3K-Akt signaling pathway Focal adhesion NF-kappa B signaling pathway Apoptosis Autophagy Necroptosis Protein processing in endoplasmic reticulum NOD-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications ER Stress pathway Neurotrophin signaling pathway
Protein Families	Bcl-2 family
Tissue Specificity	Expressed in a variety of tissues.
Weight	22,337 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHA10559618	CSB-PA129411	100ul	$297		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.