Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.Bratt A., Gene 298:69-77(2002).Bratt A., Gene 310:231-231(2003).Yu L.-R., J. Proteome Res. 6:4150-4162(2007).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human AMOTL1.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Bratt A., Gene 298:69-77(2002). Bratt A., Gene 310:231-231(2003). Yu L.-R., J. Proteome Res. 6:4150-4162(2007).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total AMOTL1 protein.
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Protein Families
Angiomotin family
Weight
101,179 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.