A kinase anchor protein 1; mitochondrial precursor; A-kinase anchor protein 149 kDa; AKAP 149; AKAP149
Antigen
AKAP1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.Trendelenburg G., Biochem. Biophys. Res. Commun. 225:313-319(1996).Lin R.-Y., J. Biol. Chem. 270:27804-27811(1995).Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human AKAP1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Trendelenburg G., Biochem. Biophys. Res. Commun. 225:313-319(1996). Lin R.-Y., J. Biol. Chem. 270:27804-27811(1995). Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total AKAP1 protein.
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Tissue Specificity
Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine (PubMed:8769136). Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain (PubMed:7499250).
Weight
62,921 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.