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Home / Primary Antibodies / IHC Antibodies

ADD1 (Ab-726) Antibody

SKU : BHA10559638

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA592573
Alternative Names	ADDA; Erythrocyte adducin alpha subunit;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30; 102(35): 12407-12Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01; 332(2): 347-51Barkalow KL, et al. J Cell Biol 2003 May 12; 161(3): 557-70
Host	Rabbit
Immunogen	Peptide sequence around aa.724~728 (T-P-S-F-L) derived from Human ADD1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30; 102(35): 12407-12 Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01; 332(2): 347-51 Barkalow KL, et al. J Cell Biol 2003 May 12; 161(3): 557-70
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total ADD1 protein.
Subcellular Location	Cytoplasm, cytoskeleton, Cell membrane, Peripheral membrane protein, Cytoplasmic side

Uniprot	P35611
Gene Id	118
Database Links	HGNC:243 OMIM:102680 KEGG:hsa:118 STRING:9606.ENSP00000264758 UniGene:Hs.183706
Function	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Protein Families	Aldolase class II family, Adducin subfamily
Tissue Specificity	Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Weight	80,955 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559638	CSB-PA592573	100ul	$297		Add to Cart

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