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Home / Primary Antibodies / IHC Antibodies

ACVR2B Antibody

SKU : BHA10550160

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA292270
Alternative Names	activin A receptor, type IIB
Categories	Primary Antibodies
Description	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Host	Rabbit
Immunogen	Fusion protein of Human ACVR2B
Involvement In Disease	Heterotaxy, visceral, 4, autosomal (HTX4)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Species	Homo Sapiens (Human)
Subcellular Location	Cell membrane, Single-pass type I membrane protein

Uniprot	Q13705
Gene Id	93
Database Links	HGNC:174 OMIM:602730 KEGG:hsa:93 STRING:9606.ENSP00000340361 UniGene:Hs.174273
Function	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
Pathway	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Weight	57,724 Da

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

ELISA	1:1000-1:2000
IHC	1:25-1:100

Tested Application

ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:25-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10550160	CSB-PA292270	100ul	$299		Add to Cart
BHA10550160	CSB-PA292270	50ul	$166		Add to Cart

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