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Home / Primary Antibodies / IHC Antibodies

ACMSD Antibody

SKU : BHA10551316

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA297536
Alternative Names	aminocarboxymuconate semialdehyde decarboxylase
Categories	Primary Antibodies
Description	The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
Host	Rabbit
Immunogen	Fusion protein of Human ACMSD
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
Species	Homo Sapiens (Human)

Uniprot	Q8TDX5
Gene Id	130013
Database Links	HGNC:19288 OMIM:608889 KEGG:hsa:130013 STRING:9606.ENSP00000348459 UniGene:Hs.655728
Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Protein Families	Metallo-dependent hydrolases superfamily, ACMSD family
Weight	31,213 Da

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

ELISA	1:1000-1:2000
IHC	1:15-1:50

Tested Application

ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:15-1:50

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10551316	CSB-PA297536	100ul	$299		Add to Cart
BHA10551316	CSB-PA297536	50ul	$166		Add to Cart

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