Anti-undefined Antibody C40,1605 Unconjugated BHA10208124

Mfr.No.	958-MSM1-P1ABX
Alternative Names	B-cell surface antigen CD40 ; Bp50 ; CD40 ; CD40L receptor ; GP39 ; HIGM1 ; IGM ; IMD3 ; p50 ; TBAM ; TNF receptor superfamily member 5 ; TNFRSF5 ; TRAP
Categories	Primary Antibodies
Cellular Localization	Secreted, Cell Surface
Chromosome Location	20q12-q13.2
Clonality	monoclonal
Description	CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
Host	Mouse
Immunogen	Recombinant full-length human CD40 protein
Isotype	IgG1 Kappa
Positive Control	L-428 Cells. Tonsil, Spleen or Thymus
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P25942
Gene Id	958
Clone No	C40, 1605
Symbol	CD40
Weight	43kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., IHC-F

Dilution

Immunohistology (Formalin-fixed)

1-2μg/ml for 30 minutes at RT