Anti-undefined Antibody AKT1,2552 Unconjugated BHA10208065

Mfr.No.	207-MSM2-P1ABX
Alternative Names	AKT1 ; Oncogene AKT1 ; PKB ; PKB-ALPHA ; PRKBA ; Protein Kinase B Alpha ; Proto-oncogene c-Akt ; RAC Alpha ; RAC Serine/Threonine Protein Kinase ; RAC-alpha serine/threonine-protein kinase ; RAC-PK-alpha
Categories	Primary Antibodies
Cellular Localization	Nuclear, Cytoplasmic, Cell Surface
Chromosome Location	14q32.32
Clonality	monoclonal
Description	Recognizes a protein of 62kDa, which is identified as AKT1. The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKB? or RacPK-?) and Akt 3 (also designated PKB? or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-? tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin.
Host	Mouse
Immunogen	Recombinant human AKT1 protein fragment (around aa 85-189) (exact sequence is proprietary)
Isotype	IgG2b Kappa
Positive Control	PDGF-treated NIH/3T3 cells. HeLa cell lysates. Human pancreas or cervical carcinoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P31749
Gene Id	207
Clone No	AKT1, 2552
Symbol	AKT1
Weight	62kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., IHC-F

Dilution

Immunohistology (Formalin-fixed)

1-2μg/ml for 30 min at RT

No Description Available.

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10208065	207-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-undefined Antibody AKT1,2552 Unconjugated BHA10208065

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